Invasive lobular carcinoma

 Invasive lobular carcinoma is breast cancer arising from the lobules of the mammary glands.^[1] It accounts for 5-10% of invasive breast cancer.^[2][3]

Invasive lobular carcinoma
Lobules of the mammary glands.
Specialty	Oncology

Histopathologic types of breast cancer, with relative incidences and prognoses, with "invasive lobular carcinoma" at top right.

The histologic patterns include:^[4][5][6]

Type	Prevalence	Description	Image
Classical	40%	round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a targetoid pattern
Mixed	40%	No dominant pattern
Solid	10%	Sheets of classical-appearing cells with little intervening stroma
Alveolar	5%	Aggregates of classical-appearing cells
Tubulolobular	5%	Cells form microtubules in >90% of tumor (smaller than in tubular carcinoma)
Pleomorphic		Classical-appearing but with pleomorphic cells

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  Histopathology of invasive lobular carcinoma (ILC), next to lobular carcinoma in situ (LCIS).

 

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  Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern.

 

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Lobular breast cancer. Single file cells and cell nests.

Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.^[7]

Loss of E-cadherin is common in lobular carcinoma but is also seen in other breast cancers.^[8]

Treatment includes surgery and adjuvant therapy.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.